In order to find answers to these key questions, experimental models are necessary. doi: 10.1016/20 Pub Med Abstract | Cross Ref Full Text | Google Scholar Schneider, T. In this review, we provide information on archaeal organisms and on some exceptional bacteria that carry Groups I and II (or Group II-like) chaperonin genes, which have potential as experimental models to study human chaperonopathies. All archaea have a chaperonin of Group II (thermosome) in their cytoplasm and some have also a chaperonin of Group I (Gro EL; Cpn60; Hsp60). Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy. Conversely, all bacteria have Gro EL, some in various copies, but only a few have, in addition, a chaperonin (tentatively designated Group III chaperonin) very similar to that occurring in all archaea, i.e., the thermosome subunit, and in the cytosol of eukaryotic cells, named CCT.
Information on these key issues is necessary to make progress in diagnosis and treatment.
In this article, we will focus on the chaperonins of Group II, namely the CCT chaperonins, since there are reports on diseases caused by mutations of human cct genes. Genomic sequence of hyperthermophile, Pyrococcus furiosus: implications for physiology and enzymology.
Fourteen cct genes, including canonical and non-canonical family members, have been identified in the human genome (Table 1; Mukherjee et al., 2010), and mutations in several of them have been found to cause heritable disease (Table 2).
The main objective is to present this novel area of research to the scientific community so interest in these serious diseases might be ignited and projections into other similar disorders might be perceived. doi: 10.1006/jsbi.2001.4402 Pub Med Abstract | Cross Ref Full Text | Google Scholar Sahlan, M., Zako, T., Tai, P.
It is hoped that innovative research on these and many other conditions with comparable etiopathogenic characteristics, involving abnormal chaperones, will be initiated applying the prokaryotic models discussed.
It may be assumed that many more cases of this kind of diseases will be found when the medical community becomes aware of the existence and high prevalence of chaperonopathies, genetic and acquired. The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum. doi: 10.1038/35035069 Pub Med Abstract | Cross Ref Full Text | Google Scholar Ruepp, A., Rockel, B., Gutsche, I., Baumeister, W., and Lupas, A.